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Site-specific accumulation of recently activated CD4+Foxp3+ regulatory T cells following adoptive transfer
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A multiply redundant genetic switch 'locks in' the transcriptional signature of regulatory T cells
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Immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome: a paradigm of immunodeficiency with autoimmunity
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Tregs prevent GVHD and promote immune reconstitution in HLA-haploidentical transplantation
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Therapeutic in vivo selection of thymic-derived natural T regulatory cells following non-myeloablative hematopoietic stem cell transplant for IPEX
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Forkhead box protein 3 (FOXP3) mutations lead to increased TH17 cell numbers and regulatory T-cell instability
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Human Regulatory T Cells with Alloantigen Specificity Are More Potent Inhibitors of Alloimmune Skin Graft Damage than Polyclonal Regulatory T Cells
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Immune intervention with T regulatory cells: Past lessons and future perspectives for type 1 diabetes
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Reduced Expression of FOXP3 and Regulatory T-Cell Function in Severe Forms of Early-onset Autoimmune Enteropathy
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Expression of Helios, an Ikaros Transcription Factor Family Member, Differentiates Thymic-Derived from Peripherally Induced Foxp3(+) T Regulatory Cells
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Selective engraftment of donor CD4+25high FOXP3-positive T cells in IPEX syndrome after nonmyeloablative hematopoietic stem cell transplantation
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BLOOD (2009)
Wild-type FOXP3 is selectively active in CD4+CD25hi regulatory T cells of healthy female carriers of different FOXP3 mutations
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First-in-man clinical results of the treatment of patients with graft versus host disease with human ex vivo expanded CD4+CD25+CD127-T regulatory cells
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Plasticity of CD4(+) FoxP3(+) T cells
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FOXP3 Forkhead Domain Mutation and Regulatory T Cells in the IPEX Syndrome
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NEW ENGLAND JOURNAL OF MEDICINE (2009)
Gene Therapy for Immunodeficiency Due to Adenosine Deaminase Deficiency.
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Identification of IL-17-producing FOXP3+ regulatory T cells in humans
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Forced overexpression of either of the two common human Foxp3 isoforms can induce regulatory T cells from CD4+CD25- cells
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EUROPEAN JOURNAL OF IMMUNOLOGY (2008)
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IPEX, FOXP3 and regulatory T-cells: a model for autoimmunity
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IMMUNOLOGIC RESEARCH (2007)
FOXP3 controls regulatory T cell function through cooperation with NFAT
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Defective regulatory and effector T cell functions in patients with FOXP3 mutations
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MHC class II expression identifies functionally distinct human regulatory T cells
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Suicide gene therapy of graft-versus-host disease induced by central memory human T lymphocytes
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Coordinate dual-gene transgenesis by lentiviral vectors carrying synthetic bidirectional promoters
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NATURE BIOTECHNOLOGY (2005)
Human T regulatory cells can use the perforin pathway to cause autologous target cell death
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IMMUNITY (2004)
HIV infection of naturally occurring and genetically reprogrammed human regulatory T-cells
K Oswald-Richter et al.
PLOS BIOLOGY (2004)
Crucial role of FOXP3 in the development and function of human CD25+CD4+ regulatory T cells
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Rescue of the autoimmune scurfy mouse by partial bone marrow transplantation or by injection with T-enriched splenocytes
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