期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 5, 期 173, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3004978
关键词
-
资金
- Merrill Palmer Skillman Institute for Child and Family Development
- Department of Pediatrics, Wayne State University (WSU) School of Medicine
- WSU Perinatal Initiative
- Intramural Research Program of the Eunice Kennedy Shriver NICHD, NIH, Department of Health and Human Services [N01-HD-2-3342]
- NIH/NINDS [NS 055064]
- WSU's Perinatology Virtual Discovery Grant [P3018205]
- WSU's Research Grant Program awards
Compelling evidence indicates that psychiatric and developmental disorders are generally caused by disruptions in the functional connectivity (FC) of brain networks. Events occurring during development, and in particular during fetal life, have been implicated in the genesis of such disorders. However, the developmental timetable for the emergence of neural FC during human fetal life is unknown. We present the results of resting-state functional magnetic resonance imaging performed in 25 healthy human fetuses in the second and third trimesters of pregnancy (24 to 38 weeks of gestation). We report the presence of bilateral fetal brain FC and regional and age-related variation in FC. Significant bilateral connectivity was evident in half of the 42 areas tested, and the strength of FC between homologous cortical brain regions increased with advancing gestational age. We also observed medial to lateral gradients in fetal functional brain connectivity. These findings improve understanding of human fetal central nervous system development and provide a basis for examining the role of insults during fetal life in the subsequent development of disorders in neural FC.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据