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Lluis Ballell et al.
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Shyeilla Dhuria et al.
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Jon Cohen
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Sarah A. Stanley et al.
ACS CHEMICAL BIOLOGY (2012)
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Valentina La Rosa et al.
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Kapil Tahlan et al.
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Cristian Varela et al.
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Weijia Zheng et al.
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Katherine A. Sacksteder et al.
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Christian Lienhardt et al.
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Andreas H. Diacon et al.
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Stewart T. Cole
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Anna E. Grzegorzewicz et al.
NATURE CHEMICAL BIOLOGY (2012)
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Joanne Bowes et al.
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David O. Nettleton et al.
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Takushi Kaneko et al.
FUTURE MEDICINAL CHEMISTRY (2011)
Discovery and characterization of a unique mycobacterial heme acquisition system
Michael V. Tullius et al.
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Xueying Cao et al.
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Optimisation of Bioluminescent Reporters for Use with Mycobacteria
Nuria Andreu et al.
PLOS ONE (2010)
A chemical genetic screen in Mycobacterium tuberculosis identifies carbon-source-dependent growth inhibitors devoid of in vivo efficacy
Kevin Pethe et al.
NATURE COMMUNICATIONS (2010)
Clinical Pharmacology and Lesion Penetrating Properties of Second-and Third-Line Antituberculous Agents Used in the Management of Multidrug-Resistant (MDR) and Extensively-Drug Resistant (XDR) Tuberculosis
Veronique Dartois et al.
CURRENT CLINICAL PHARMACOLOGY (2010)
Prediction of Human Pharmacokinetics From Preclinical Information: Comparative Accuracy of Quantitative Prediction Approaches
Natilie A. Hosea et al.
JOURNAL OF CLINICAL PHARMACOLOGY (2009)
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Vadim Makarov et al.
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Bernard Faller
CURRENT DRUG METABOLISM (2008)
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Liping Zhou et al.
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High-throughput in vitro profiling assays:: lessons learnt from experiences at Novartis
Bernard Faller et al.
EXPERT OPINION ON DRUG METABOLISM & TOXICOLOGY (2006)
OPC-67683, a nitro-dihydro-imidazooxazole derivative with promising action against tuberculosis in vitro and in mice
Makoto Matsumoto et al.
PLOS MEDICINE (2006)
Identification of a nitroimidazo-oxazine-specific protein involved in PA-824 resistance in Mycobacterium tuberculosis
UH Manjunatha et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Single-nucleotide polymorphism-based population genetic analysis of Mycobacterium tuberculosis strains from 4 geographic sites
MM Gutacker et al.
JOURNAL OF INFECTIOUS DISEASES (2006)
Pharmacodynamics and pharmacokinetics of SQ109, a new diamine-based antitubercular drug
J Jia et al.
BRITISH JOURNAL OF PHARMACOLOGY (2005)
Contribution of the Mycobacterium tuberculosis MmpL protein family to virulence and drug resistance
P Domenech et al.
INFECTION AND IMMUNITY (2005)
Pathway to synthesis and processing of mycolic acids in Mycobacterium tuberculosis
K Takayama et al.
CLINICAL MICROBIOLOGY REVIEWS (2005)
A diarylquinoline drug active on the ATP synthase of Mycobacterium tuberculosis
K Andries et al.
SCIENCE (2005)
The transcriptional responses of Mycobacterium tuberculosis to inhibitors of metabolism -: Novel insights into drug mechanisms of action
HIM Boshoff et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
The use of in vitro metabolic stability for rapid selection of compounds in early discovery based on their expected hepatic extraction ratios
YY Lau et al.
PHARMACEUTICAL RESEARCH (2002)
Massive gene decay in the leprosy bacillus
ST Cole et al.
NATURE (2001)
Predicting transmembrane protein topology with a hidden Markov model: Application to complete genomes
A Krogh et al.
JOURNAL OF MOLECULAR BIOLOGY (2001)
A small-molecule nitroimidazopyran drug candidate for the treatment of tuberculosis
CK Stover et al.
NATURE (2000)
Characterization of the Mycobacterium tuberculosis iniBAC promoter, a promoter that responds to cell wall biosynthesis inhibition
D Alland et al.
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