期刊
SCIENCE TRANSLATIONAL MEDICINE
卷 4, 期 117, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scitranslmed.3003008
关键词
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资金
- Damon Runyon Clinical Investigator Award [R01 AR056720]
- NIH/National Cancer Institute [P50 CA9368305]
- NIH/National Institute of Allergy and Infectious Diseases [R01 A1025082]
- Swiss National Science Foundation
- Fondation Rene Touraine
Cutaneous T cell lymphoma (CTCL) is a cancer of skin-homing T cells with variants that include leukemic CTCL (L-CTCL), a malignancy of central memory T cells (T-CM), and mycosis fungoides (MF), a malignancy of skin resident effector memory T cells (T-EM). We report that low-dose alemtuzumab (alpha CD52) effectively treated patients with refractory L-CTCL but not MF. Alemtuzumab depleted all T cells in blood and depleted both benign and malignant T-CM from skin, but a diverse population of skin resident T-EM remained in skin after therapy. T cell depletion with alemtuzumab required the presence of neutrophils, a cell type frequent in blood but rare in normal skin. These data suggest that T-CM were depleted because they recirculate between the blood and the skin, whereas skin resident T-EM were spared because they are sessile and non-recirculating. After alemtuzumab treatment, skin T cells produced lower amounts of interleukin-4 and higher amounts of interferon-gamma. Moreover, there was a marked lack of infections in alemtuzumab-treated L-CTCL patients despite the complete absence of T cells in the blood, suggesting that skin resident T-EM can protect the skin from pathogens even in the absence of T cell recruitment from the circulation. Together, these data suggest that alemtuzumab may treat refractory L-CTCL without severely compromising the immune response to infection by depleting circulating T-CM but sparing the skin resident T-EM that provide local immune protection of the skin.
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