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PIP4K beta interacts with and modulates nuclear localization of the high-activity PtdIns5P-4-kinase isoform PIP4K alpha
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The tuberous sclerosis protein TSC2 is not required for the regulation of the mammalian target of rapamycin by amino acids and certain cellular stresses
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JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Dissociation of raptor from mTOR is a mechanism of rapamycin-induced inhibition of mTOR function
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The LKB1 tumor suppressor negatively regulates mTOR signaling
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CANCER CELL (2004)
Increased insulin sensitivity and reduced adiposity in phosphatidylinositol 5-phosphate 4-kinase β-/- mice
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The phosphatidylinositol (PI)-5-phosphate 4-kinase type II enzyme controls insulin signaling by regulating PI-3,4,5-trisphosphate degradation
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Tuberous sclerosis complex-1 and -2 gene products function together to inhibit mammalian target of rapamycin (mTOR)-mediated downstream signaling
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Tsc tumour suppressor proteins antagonize amino-acid-TOR signalling
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MTOR interacts with Raptor to form a nutrient-sensitive complex that signals to the cell growth machinery
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Staurosporine inhibits phosphorylation of translational regulators linked to mTOR
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