期刊
SCIENCE SIGNALING
卷 6, 期 266, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.2003906
关键词
-
资金
- Equipe Labelisee Ligue Contre le Cancer
- National Cancer Institute [PLBIO10-155]
- Creative Research Initiatives Program (Research Center for Chromatin Dynamics) [2009-0081563]
- NIH [R01 GM084465]
- Canadian Institutes of Health Research [MOP-93778]
- Deutsche Forschungsgemeinschaft [SFB366-C13, HU881/6-1]
- Medical Research Council UK
- Biotechnology and Biological Sciences Research Council
- Cancer Research UK
- European Synchrotron Research Facility (Grenoble, France)
- Bayer (Berlin, Germany)
- SPINE2-COMPLEXES project [LSHG-CT-2006-031220]
Pontin (also known as RUVBL1 and RVB1) and Reptin (also called RUVBL2 and RVB2) are related members of the large AAA+ (adenosine triphosphatase associated with diverse cellular activities) superfamily of conserved proteins. Various cellular functions depend on Pontin and Reptin, mostly because of their functions in the assembly of protein complexes that play a role in the regulation of cellular energetic metabolism, transcription, chromatin remodeling, and the DNA damage response. Little is known, though, about the interconnections between these multiple functions, how the relevant signaling pathways are regulated, whether the interconnections are affected in human disease, and whether components of these pathways are suitable targets for therapeutic intervention. The First International Workshop on Pontin (RUVBL1) and Reptin (RUVBL2), held between 16 and 19 October 2012, discussed the nature of the oligomeric organization of these proteins, their structures, their roles as partners in various protein complexes, and their involvement in cellular regulation, signaling, and pathophysiology, as well as their potential for therapeutic targeting. A major outcome of the meeting was a general consensus that most functions of Pontin and Reptin are related to their roles as chaperones or adaptor proteins that are important for the assembly and function of large signaling protein complexes.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据