相关参考文献
注意：仅列出部分参考文献，下载原文获取全部文献信息。Blocking the mTOR pathway: a drug discovery perspective
Carlos Garcia-Echeverria
BIOCHEMICAL SOCIETY TRANSACTIONS (2011)
Parameter estimation in systems biology models using spline approximation
Choujun Zhan et al.
BMC SYSTEMS BIOLOGY (2011)
Activation of mTORC2 by Association with the Ribosome
Vittoria Zinzalla et al.
CELL (2011)
Amino Acids Activate Mammalian Target of Rapamycin Complex 2 (mTORC2) via PI3K/Akt Signaling
Irantzu Tato et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
Evidence for Direct Activation of mTORC2 Kinase Activity by Phosphatidylinositol 3,4,5-Trisphosphate
Xiaoqing Gan et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2011)
mTORC2 Is Required for Proliferation and Survival of TSC2-Null Cells
Elena A. Goncharova et al.
MOLECULAR AND CELLULAR BIOLOGY (2011)
mTOR: from growth signal integration to cancer, diabetes and ageing
Roberto Zoncu et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2011)
The long and winding road to rational treatment of cancer associated with LKB1/AMPK/TSC/mTORC1 signaling
W. van Veelen et al.
ONCOGENE (2011)
Phosphoproteomic Analysis Identifies Grb10 as an mTORC1 Substrate That Negatively Regulates Insulin Signaling
Yonghao Yu et al.
SCIENCE (2011)
The mTOR-Regulated Phosphoproteome Reveals a Mechanism of mTORC1-Mediated Inhibition of Growth Factor Signaling
Peggy P. Hsu et al.
SCIENCE (2011)
mTOR couples cellular nutrient sensing to organismal metabolic homeostasis
Jessica J. Howell et al.
TRENDS IN ENDOCRINOLOGY AND METABOLISM (2011)
Ragulator-Rag Complex Targets mTORC1 to the Lysosomal Surface and Is Necessary for Its Activation by Amino Acids
Yasemin Sancak et al.
CELL (2010)
A Ras Signaling Complex Controls the RasC-TORC2 Pathway and Directed Cell Migration
Pascale G. Charest et al.
DEVELOPMENTAL CELL (2010)
Classic and contemporary approaches to modeling biochemical reactions
William W. Chen et al.
GENES & DEVELOPMENT (2010)
Second AKT: The rise of SGK in cancer signalling
Maressa A. Bruhn et al.
GROWTH FACTORS (2010)
mTOR Ser-2481 Autophosphorylation Monitors mTORC-specific Catalytic Activity and Clarifies Rapamycin Mechanism of Action
Ghada A. Soliman et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Mass and Information Feedbacks through Receptor Endocytosis Govern Insulin Signaling as Revealed Using a Parameter-free Modeling Framework
Cecilia Brannmark et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2010)
Ras-mediated activation of the TORC2-PKB pathway is critical for chemotaxis
Huaqing Cai et al.
JOURNAL OF CELL BIOLOGY (2010)
Involvement of the Cytoskeleton in Controlling Leading-Edge Function during Chemotaxis
Susan Lee et al.
MOLECULAR BIOLOGY OF THE CELL (2010)
Regulation of the mTOR Complex 1 Pathway by Nutrients, Growth Factors, and Stress
Shomit Sengupta et al.
MOLECULAR CELL (2010)
A comprehensive map of the mTOR signaling network
Etienne Caron et al.
MOLECULAR SYSTEMS BIOLOGY (2010)
The emerging mechanisms of isoform-specific PI3K signalling
Bart Vanhaesebroeck et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
The nuts and bolts of AGC protein kinases
Laura R. Pearce et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2010)
Modelling the Response of FOXO Transcription Factors to Multiple Post-Translational Modifications Made by Ageing-Related Signalling Pathways
Graham R. Smith et al.
PLOS ONE (2010)
Inferring Signaling Pathway Topologies from Multiple Perturbation Measurements of Specific Biochemical Species
Tian-Rui Xu et al.
SCIENCE SIGNALING (2010)
Rapamycin inhibits mTORC1, but not completely
Carson C. Thoreen et al.
AUTOPHAGY (2009)
Activation of mTORC1 in two steps: Rheb-GTP activation of catalytic function and increased binding of substrates to raptor
Joseph Avruch et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
Rag proteins regulate amino-acid-induced mTORC1 signalling
Yasemin Sancak et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
A complex interplay between Akt, TSC2 and the two mTOR complexes
Jingxiang Huang et al.
BIOCHEMICAL SOCIETY TRANSACTIONS (2009)
TORC-Specific Phosphorylation of Mammalian Target of Rapamycin (mTOR): Phospho-Ser2481 Is a Marker for Intact mTOR Signaling Complex 2
Jeremy Copp et al.
CANCER RESEARCH (2009)
Systems Biology Reveals New Strategies for Personalizing Cancer Medicine and Confirms the Role of PTEN in Resistance to Trastuzumab
Dana Faratian et al.
CANCER RESEARCH (2009)
Signaling Events Downstream of Mammalian Target of Rapamycin Complex 2 Are Attenuated in Cells and Tumors Deficient for the Tuberous Sclerosis Complex Tumor Suppressors
Jingxiang Huang et al.
CANCER RESEARCH (2009)
mTOR and the control of whole body metabolism
Pazit Polak et al.
CURRENT OPINION IN CELL BIOLOGY (2009)
An ATP-competitive Mammalian Target of Rapamycin Inhibitor Reveals Rapamycin-resistant Functions of mTORC1
Carson C. Thoreen et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2009)
Improved semiquantitative Western blot technique with increased quantification range
F. Heidebrecht et al.
JOURNAL OF IMMUNOLOGICAL METHODS (2009)
Site-Specific mTOR Phosphorylation Promotes mTORC1-Mediated Signaling and Cell Growth
Hugo A. Acosta-Jaquez et al.
MOLECULAR AND CELLULAR BIOLOGY (2009)
Quantification of the effect of amino acids on an integrated mTOR and insulin signaling pathway
Palakkad Krishnan Unni Vinod et al.
MOLECULAR BIOSYSTEMS (2009)
Systems-level interactions between insulin-EGF networks amplify mitogenic signaling
Nikolay Borisov et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
Harmonic oscillator model of the insulin and IGF1 receptors' allosteric binding and activation
Vladislav V. Kiselyov et al.
MOLECULAR SYSTEMS BIOLOGY (2009)
The Systems Biology Graphical Notation
Nicolas Le Novere et al.
NATURE BIOTECHNOLOGY (2009)
TOR complex 2: a signaling pathway of its own
Nadine Cybulski et al.
TRENDS IN BIOCHEMICAL SCIENCES (2009)
Active-Site Inhibitors of mTOR Target Rapamycin-Resistant Outputs of mTORC1 and mTORC2
Morris E. Feldman et al.
PLOS BIOLOGY (2009)
Signaling Logic of Activity-Triggered Dendritic Protein Synthesis: An mTOR Gate But Not a Feedback Switch
Pragati Jain et al.
PLOS COMPUTATIONAL BIOLOGY (2009)
TOR regulation of AGC kinases in yeast and mammals
Estela Jacinto et al.
BIOCHEMICAL JOURNAL (2008)
mTOR complex 2 (mTORC2) controls hydrophobic motif phosphorylation and activation of serum- and glucocorticoid-induced protein kinase 1 (SGK1)
Juan M. Garcia-Martinez et al.
BIOCHEMICAL JOURNAL (2008)
PIP3-independent activation of TorC2 and PKB at the cell's leading edge mediates chemotaxis
Yoichiro Kamimura et al.
CURRENT BIOLOGY (2008)
Regulation of proline-rich Akt substrate of 40 kDa (PRAS40) function by mammalian target of rapamycin complex 1 (mTORC1)-mediated phosphorylation
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2008)
Regulation of Akt/PKB activity by P21-activated kinase in cardiomyocytes
Kai Mao et al.
JOURNAL OF MOLECULAR AND CELLULAR CARDIOLOGY (2008)
The TSC1-TSC2 complex is required for proper activation of mTOR complex 2
Jingxiang Huang et al.
MOLECULAR AND CELLULAR BIOLOGY (2008)
PKBα/Akt1 acts downstream of DNA-PK in the DNA double-strand break response and promotes survival
Lana Bozulic et al.
MOLECULAR CELL (2008)
Models from experiments: combinatorial drug perturbations of cancer cells
Sven Nelander et al.
MOLECULAR SYSTEMS BIOLOGY (2008)
Model-based hypothesis testing of key mechanisms in initial phase of insulin signaling
Gunnar Cedersund et al.
PLOS COMPUTATIONAL BIOLOGY (2008)
The Signaling Petri Net-Based Simulator: A Non-Parametric Strategy for Characterizing the Dynamics of Cell-Specific Signaling Networks
Derek Ruths et al.
PLOS COMPUTATIONAL BIOLOGY (2008)
PRAS40 and PRR5-Like Protein Are New mTOR Interactors that Regulate Apoptosis
Kathrin Thedieck et al.
PLOS ONE (2007)
Ensemble modeling for analysis of cell signaling dynamics
Lars Kuepfer et al.
NATURE BIOTECHNOLOGY (2007)
PRAS40 is a target for mammalian target of rapamycin complex 1 and is required for signaling downstream of this complex
Bruno D. Fonseca et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
The proline-rich akt substrate of 40 kDa (PRAS40) is a physiological substrate of mammalian target of rapamycin complex 1
Noriko Oshiro et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
PRAS40 regulates mTORC1 kinase activity by functioning as a direct inhibitor of substrate binding
Lifu Wang et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2007)
PRAS40 is an insulin-regulated inhibitor of the mTORC1 protein kinase
Yasemin Sancak et al.
MOLECULAR CELL (2007)
Insulin signalling to mTOR mediated by the Akt/PKB substrate PRAS40
Emilie Vander Haar et al.
NATURE CELL BIOLOGY (2007)
COPASI- A COmplex PAthway SImulator
Stefan Hoops et al.
BIOINFORMATICS (2006)
SIN1/MIP1 maintains rictor-mTOR complex integrity and regulates Akt phosphorylation and substrate specificity
Estela Jacinto et al.
CELL (2006)
Multiallelic disruption of the rictor gene in mice reveals that mTOR complex 2 is essential for fetal growth and viability
Chiyo Shiota et al.
DEVELOPMENTAL CELL (2006)
SBMLToolbox: an SBML toolbox for MATLAB users
SM Keating et al.
BIOINFORMATICS (2006)
TSC1/TSC2 and Rheb have different effects on TORC1 and TORC2 activity
Q Yang et al.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA (2006)
Systems Biology Toolbox for MATLAB: a computational platform for research in systems biology
H Schmidt et al.
BIOINFORMATICS (2006)
mTOR•RICTOR is the Ser473 kinase for Akt/protein kinase B in 3T3-L1 adipocytes
RC Hresko et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Tor2 directly phosphorylates the AGC kinase Ypk2 to regulate actin polarization
Y Kamada et al.
MOLECULAR AND CELLULAR BIOLOGY (2005)
Phosphorylation and regulation of Akt/PKB by the rictor-mTOR complex
DD Sarbassov et al.
SCIENCE (2005)
Full activation of PKB/Akt in response to insulin or ionizing radiation is mediated through ATM
JG Viniegra et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2005)
Reconstruction of cellular signalling networks and analysis of their properties
JA Papin et al.
NATURE REVIEWS MOLECULAR CELL BIOLOGY (2005)
Dysregulation of the TSC-mTOR pathway in human disease
K Inoki et al.
NATURE GENETICS (2005)
Identification of a PKB/Akt hydrophobic motif Ser-473 kinase as DNA-dependent protein kinase
JH Feng et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Regulation of protein kinase B/Akt activity and Ser473 phosphorylation by protein kinase Cα in endothelial cells
C Partovian et al.
CELLULAR SIGNALLING (2004)
Rictor, a novel binding partner of mTOR, defines a rapamycin-insensitive and raptor-independent pathway that regulates the cytoskeleton
DD Sarbassov et al.
CURRENT BIOLOGY (2004)
Protein kinase C βII regulates Akt phosphorylation on Ser-473 in a cell type- and stimulus-specific fashion
Y Kawakami et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2004)
Mammalian TOR complex 2 controls the actin cytoskeleton and is rapamycin insensitive
E Jacinto et al.
NATURE CELL BIOLOGY (2004)
Conditional suppression of cellular genes: Lentivirus vector-mediated drug-inducible RNA interference
M Wiznerowicz et al.
JOURNAL OF VIROLOGY (2003)
Conditional knock-out of integrin-linked kinase demonstrates an essential role in protein kinase B/Akt activation
AA Troussard et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2003)
The systems biology markup language (SBML):: a medium for representation and exchange of biochemical network models
M Hucka et al.
BIOINFORMATICS (2003)
Parameter estimation in biochemical pathways: A comparison of global optimization methods
CG Moles et al.
GENOME RESEARCH (2003)
A mathematical model of metabolic insulin signaling pathways
AR Sedaghat et al.
AMERICAN JOURNAL OF PHYSIOLOGY-ENDOCRINOLOGY AND METABOLISM (2002)
p38 kinase-dependent MAPKAPK-2 activation functions as 3-phosphoinositide-dependent kinase-2 for Akt in human neutrophils
MJ Rane et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2001)
The segment polarity network is a robust developmental module
G von Dassow et al.
NATURE (2000)
The role of 3-phosphoinositide-dependent protein kinase 1 in activating AGC kinases defined in embryonic stem cells
MR Williams et al.
CURRENT BIOLOGY (2000)
Akt/protein kinase B is regulated by autophosphorylation at the hypothetical PDK-2 site
A Toker et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
FKBP12-rapamycin-associated protein (FRAP) autophosphorylates at serine 2481 under translationally repressive conditions
RT Peterson et al.
JOURNAL OF BIOLOGICAL CHEMISTRY (2000)
分享论文
