期刊
SCIENCE SIGNALING
卷 3, 期 127, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/scisignal.3127pe21
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资金
- Howard Hughes Medical Institute Funding Source: Medline
- NICHD NIH HHS [R37 HD021502, R01 HD021502-24, HD21502-23, R01 HD021502] Funding Source: Medline
Wnt signal transduction plays a crucial role in stem cell proliferation and regeneration. When canonical Wnt signaling is low, heads develop, and when it is high, tails are formed. In planarians, Wnt transcription is activated by wounding in a beta-catenin-independent way. Hedgehog is one of the signals involved, because it induces regeneration of tails (instead of heads) through the activation of Wnt transcription. Depletion of Smad4 blocks regeneration entirely, which suggests that the bone morphogenetic protein signaling pathway and the Wnt pathway are required for regeneration and body patterning.
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