期刊
SCIENCE SIGNALING
卷 1, 期 17, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/stke.117pe17
关键词
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Bone remodeling is the result of the coordinated activity of osteoblasts, which form new matrix, and osteoclasts, which resorb bone. Notch proteins are single-pass transmembrane receptors that determine cell fate. Recent gain-of-function and loss-of-function experiments reveal a suppressive effect of Notch in osteoblast and osteoclast differentiation in development and in the postnatal bone, which establishes a role for Notch signaling in bone remodeling.
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