期刊
SCIENCE SIGNALING
卷 1, 期 10, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/stke.110pe13
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资金
- NCRR NIH HHS [S10 RR022575-01A1, S10 RR022575] Funding Source: Medline
- NHLBI NIH HHS [R01 HL062352-09A1, R01 HL062352] Funding Source: Medline
- NIAMS NIH HHS [R21 AR056128, R21 AR056128-01A1, R21 AR056128-02] Funding Source: Medline
- NIBIB NIH HHS [R01 EB007049, R01 EB007049-01, R01 EB007049-03, R01 EB007049-02] Funding Source: Medline
Soluble growth factors are potent regulators of normal and pathological processes. Mechanical factors are emerging as similarly important, but there has been no obvious mechanism linking the different factors. Are centre port now demonstrates that cell-generated mechanical tension results in release of active transforming growth factor-beta from stiff extracellular matrix, providing a mechanism for differentiation and maintenance of myofibroblasts in processes like fibrosis. More broadly, the work suggests that matrix stiffness could regulate the equilibrium between storage and release of a host of matrix-bound growth factors.
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