期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 423, 期 -, 页码 151-161出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2012.02.001
关键词
Human biomonitoring; Health survey; Persistent organic pollutants; Pesticide residues; Environmental pollutants; Environmental exposure/human samples
资金
- Department of Health, Government of Catalonia
- 'Red tematica de investigacion cooperativa de centros en Cancer' [C03/10]
- 'Red tematica de investigacion cooperativa de centros en Epidemiologia y salud publica' [C03/09]
- CIBER de Epidemiologia, Instituto de Salud Carlos III, Ministry of Health, Government of Spain
Introduction: POP biomonitoring programs are useful for exposure assessment, to analyze patterns, and to evaluate policies. However, population-representative surveys are scarce and heterogeneous. Reports on time trends in representative samples using the same methods are rare. Objectives: To analyze the distribution of serum concentrations of 19 POPs in the general population of Barcelona city in 2006, and to compare it with the distribution in 2002. Methods: 231 participants in the Barcelona Health Survey were interviewed face-to-face, gave blood, and underwent a physical exam. Density plots (POP Geoffrey Rose curves) were used to represent the full population distribution of each compound. Results: Eight POPS were each detected in >80% of the study subjects: p,p'-DDT, p,p'-DDE, PCB congeners 118, 138, 153 and 180, HCB and beta-HCH. The minimum number of POPs detected in one person was 5, and 72% of the population accumulated >= 10 compounds. p,p'-DDE and HCB showed the highest concentrations (median = 219 and 109 ng/g lipid, respectively). Concentrations decreased by 34-56% from 2002 to 2006. The decrease was similar in women and men, and in all age groups/birth cohorts. It was larger with increasing BM: for p,p'-DDT, HCB and beta-HCH the decrease in obese individuals was 31-44 percentage points larger than in subjects with normal weight The distribution of POP concentrations was always switched towards higher values in women than men. POP levels also differed significantly by age, body mass index, weight gain, birth place and social class, but not by parity and breastfeeding. The two younger cohorts had a higher DDT/DDE ratio than the oldest cohort. Conclusion: Although human POP contamination remains common in the city of Barcelona, concentrations decreased significantly in 4 years. Our approach suggests innovative ways to conceive, analyze and present results for other monitoring programs. (C) 2012 Elsevier B.V. All rights reserved.
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