期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 433, 期 -, 页码 281-289出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2012.06.035
关键词
Ibuprofen; Metabolites; QuEChERS; Soil; Extraction
资金
- Fundacao para a Ciencia e a Tecnologia [PEst-C/EQB/LA0006/2011, PTDC/ECM/103141/2008]
- Fundação para a Ciência e a Tecnologia [PTDC/ECM/103141/2008] Funding Source: FCT
Ibuprofen is one of the most used active pharmaceutical ingredients worldwide. A new method for the analysis of ibuprofen and its metabolites, hydroxyibuprofen and carboxyibuprofen, in soils is presented. The extraction of these compounds from the soil matrices was performed by using a modified quick, easy, cheap, effective, rugged, and safe (QuEChERS) method. The method involves a single extraction of the investigated compounds with purified water (acidified at pH 2.5 with hydrochloric acid), and a slow and continuous addition of the QuEChERS content, followed by the addition of acidified acetonitrile (1% acetic acid), prior to the determination by liquid chromatography coupled with fluorescence detection (LC-FLD). Validation studies were carried out using soil samples with a range of organic carbon contents. Recoveries of the fortified samples ranged from 79.5% to 101%. Relative standard deviations for all matrix-compound combinations did not exceed 3%. The method quantification limits were <= 22.4 mu g kg(-1) in all cases. The developed method was applied to the analysis of sixteen real samples. (C) 2012 Elsevier B.V. All rights reserved.
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