Assessment of organochlorine pesticides in human milk and risk exposure to infants from North-East India

Despite the worldwide ban on use of persistent organochlorine pesticides, their usage continued until recently in India, for vector-borne disease eradication programs and agricultural purposes. The concentrations of organochlorine contaminants, DDT and HCH, have been determined in human breast milk from Dibrugarh and Nagaon districts of Assam state, North-East India. The results demonstrated that the mean levels of total DDT were 3210 ng/g lipid wt. and 2870 ng/g lipid wt. and total HCH were 2720 ng/g; lipid wt. and 2330 ng/g lipid wt. in Nagaon and Dibrugarh respectively. There was no significant difference in the levels of investigated pollutants between the two districts. Significant differences in ADI (Average daily intake) for total DDT were found between the two districts. In addition, a positive correlation was observed between OCP levels in breast milk and age of mothers. Based on OCP levels in human breast milk, the ADI by the infants has been estimated. It has been found that high daily intake of DDTs and HCHs by the infants exceeded the TDI (Tolerable daily intake) which implied that infants of the region are potentially at high risk by these contaminants. (C) 2011 Elsevier B.V. All rights reserved.