期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 408, 期 4, 页码 790-795出版社
ELSEVIER
DOI: 10.1016/j.scitotenv.2009.10.007
关键词
Pesticides; Chlorpyrifos; Cord blood; Maternal blood; Pregnant women; New Jersey; Birth outcome; Birth weight
资金
- New Jersey Department of Environmental Protection [DEP SR04-058, SR05-042]
- NIEHS [P30ES005022, T32 007148]
We evaluated in utero exposures to pesticides by measuring maternal and cord serum biomarkers in a New Jersey cohort of pregnant women and the birth outcomes of their neonates. The study was based on 150 women that underwent an elective cesarean delivery at term in a hospital in central New Jersey. We evaluated the following pesticide compounds in both maternal and umbilical cord sera: chlorpyrifos, diazinon, carbofuran, chlorothalonil, dacthal, metolachlor, trifluralin and diethyl-m-toluamide (DEET). Of these compounds, chlorpyrifos, carbofuran, chlorothalonil, trifluralin, metolachlor and DEET were the pesticides most frequently detected in the serum samples. We found high (>= 75th percentile) metolachlor concentrations in cord blood that were related to birth weight (3605 g in upper quartile vs 3399 g; p = 0.05). We also observed an increase in abdominal circumference with increasing cord dichloran concentrations (p = 0.031). These observations suggest that in utero exposures to certain pesticides may alter birth outcomes. (C) 2009 Elsevier B.V. All rights reserved.
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