期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 407, 期 4, 页码 1326-1332出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2008.10.050
关键词
Electric field; N-acetyl L-cysteine; Epigallocatechin-3-gallate; Heme oxygenase-1; Protein carbonyl content; Hydroxyproline; Nitric oxide; Malondialdehyde; Lung
资金
- Gazi University Research Foundation
In order to test whether antioxidants have beneficiary effects on electric field induced damage, we determined the pulmonary levels of heme oxygenase-1 (HO-1), protein carbonyl content (PCO), malondialdehyde (MDA), nitric oxide (NO) and hydroxyproline (HP) under extremely low frequency (ELF) electric (E) field exposure (50 Hz, 12 kV/m, 7 days/for 8 h/day). While PCO levels significantly increased (p<0.05), insignificant changes (p>0.05) were observed in HO-1, MDA, NO and HP levels for electric field exposure groups compared to the control group. We have not observed any significant change in these parameters on the electric field group compared to the group where NAC and EGCG were separately applied along with electric field. However, during our previous studies, we have concluded that NAC and EGCG are potent antioxidants and we believe that new studies should be established by way of setting up different experimental conditions. (C) 2008 Elsevier B.V. All rights reserved.
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