期刊
SCIENCE OF THE TOTAL ENVIRONMENT
卷 407, 期 6, 页码 1875-1885出版社
ELSEVIER SCIENCE BV
DOI: 10.1016/j.scitotenv.2008.11.050
关键词
Arsenic; Dietary exposure; Fish; Shellfish; Biomarker
资金
- French Ministry of Agriculture and Fisheries, France
Seafood, especially fish, is considered as a major dietary source of arsenic (As). Seafood consumption is recommended for nutritional properties but contaminant exposure should be considered. The objectives were to assess As intake of frequent French seafood consumers and exposure via biomarkers. Consumptions of 996 high consumers (18 and over) of 4 coastal areas were assessed using a validated food frequency questionnaire. Seafood samples were collected according to a total diet study (TDS) sampling method and analyzed for total As, arsenite (AsIII), arsenate (AsV), arsenobetaine (AsB), monomethylarsonic acid (MMA) and dimethylarsinic acid (DMA). The average As dietary exposure is 94.7 +/- 67.5 mu g/kg bw/week in females and 77.3 +/- 54.6 mu g/kg bw/week in males (p<0.001) and the inorganic As dietary exposure is respectively 3.34 +/- 2.06 mu g/kg bw/week and 3.04 +/- 1.86 mu g/kg bw/week (p < 0.05). Urine samples were collected from 382 of the subjects. The average urinary As concentration is 94.8 +/- 250 mu g/g creatinine for females and 59.7 +/- 81.8 mu g/g for males (p<0.001). Samples having an As concentration above 75 mu g/g creatinine (n=101) were analyzed for inorganic As (As(III), As(V), MMA(V) and DMA(V)) which was 24.6 +/- 27.9 mu g/g creatinine for males and 27.1 +/- 20.6 mu g/g for females. Analyses do not show any correlation between dietary exposure and urinary As. These results show that biological results should be interpreted cautiously. Diet recording seems to be the best way to assess dietary As exposure. Seafood is a high source of As exposure but even among high consumers it is not the main source of toxic As. From a public health point of view these results should be interpreted carefully in the absence of international consensus on the health-based guidance value. (C) 2008 Elsevier B.V. All rights reserved.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据