期刊
RSC ADVANCES
卷 5, 期 45, 页码 35469-35486出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c4ra13581d
关键词
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资金
- Natural Sciences and Engineering Research Council (NSERC)
- 20/20: NSERC Ophthalmic Materials Research Network
Hydrogels based on poly(ethylene glycol) (PEG) and derivatives have attracted significant interest in recent years given their capacity to be well-tolerated in vivo in the context of drug delivery and tissue engineering applications. Injectable, in situ-gelling analogues of such hydrogels offer the additional advantages of being easy and non-invasive to administer via the injection of low-viscosity precursor polymer solutions, expanding their scope of potential applications. In this highlight, we first review the design criteria associated with the rational design of in situ-gelling hydrogels for in vivo applications. We then discuss recent progress in the design of injectable PEG hydrogels, specifically highlighting our ongoing work on PEG-analogue hydrogels based on poly(oligoethylene glycol methacrylate) for targeted biomedical applications.
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