期刊
SCIENCE CHINA-TECHNOLOGICAL SCIENCES
卷 57, 期 5, 页码 879-884出版社
SCIENCE PRESS
DOI: 10.1007/s11431-014-5529-x
关键词
channel blocks; spiking regularity; clustered neuronal networks
资金
- National Natural Science Foundation of China [11102094, 11272065]
- Fundamental Research Funds for the Central University of China [2013RC0904]
In this paper, we discuss the influences of channel blocks on the spiking regularity in a clustered neuronal network by applying stochastic Hodgkin-Huxley neuronal models as the building blocks. With the aid of simulation results, we reveal that the spiking regularity of the clustered neuronal network could be resonantly enhanced via fine-tuning of the non-blocked potassium channel fraction x (K) . While the non-blocked sodium channel fraction x (Na) can enhance the spiking regularity of the clustered neuronal network in most cases. These results indicate that not only sodium channel blocks but also potassium channel blocks could have great influences on the regularity of spike timings in the clustered neuronal networks. Considering the importance of spike timings in neuronal information transforming processes, our results may give some implications for understanding the nonnegligible role of randomness in ion channels in neuronal systems.
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