期刊
RSC ADVANCES
卷 5, 期 105, 页码 86428-86439出版社
ROYAL SOC CHEMISTRY
DOI: 10.1039/c5ra17568b
关键词
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资金
- Higher Education Commission (HEC) of Pakistan [1691]
- Organization for the Prohibition of Chemical Weapons (OPCW), The Hague, The Netherlands
- Higher Education Commission of Pakistan [20-3733/NRPU/RD/14/520]
- Canadian Institutes of Health Research (CIHR)
- Fonds de recherche du Quebec - Sante (FRQS)
We report the synthesis of a series of different substituted N-(2,3-dimethyl-5-oxo-1-phenyl-2,5-dihydro-1H-pyrazol-4-yl)benzamides by making use of a non-steroidal anti-inflammatory drug known as 4-aminophenazone also called as antipyrine, a compound of great interest in drug chemistry. These compounds possess potential biological applications and were screened against human recombinant alkaline phosphatase including human tissue-nonspecific alkaline phosphatase (h-TNAP), tissue specific human intestinal alkaline phosphatase (h-IAP), human placental alkaline phosphatase (h-PLAP) and human germ cell alkaline phosphatase (h-GCAP). These compounds were also tested for their inhibitory potential against recombinant human and rat ecto-5'-nucleotidases (h-e5-NT & r-e5-NT, respectively). All benzamide derivatives inhibited APs to a lesser degree than e5-NT. The reported compounds are of considerable interest for further applications in the field of medicinal chemistry as these compounds have potential to bind nucleotide protein targets.
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