期刊
SCIENCE CHINA-LIFE SCIENCES
卷 61, 期 10, 页码 1137-1150出版社
SCIENCE PRESS
DOI: 10.1007/s11427-018-9349-5
关键词
small molecule; in situ regeneration; adult stem cells; somatic cells; dedifferentiation; transdifferentiation; reprogramming
类别
资金
- National Natural Science Foundation of China [81721092]
- National Key R&D Program of China [2017YFC1103304]
Chemical modulation of cell fates has been widely used to promote tissue and organ regeneration. Small molecules can target the self-renewal, expansion, differentiation, and survival of endogenous stem cells for enhancing their regenerative power or induce dedifferentiation or transdifferentiation of mature cells into proliferative progenitors or specialized cell types needed for regeneration. Here, we discuss current progress and potential using small molecules to promote in vivo regenerative processes by regulating the cell fate. Current studies of small molecules in regeneration will provide insights into developing safe and efficient chemical approaches for in situ tissue repair and regeneration.
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