期刊
SCIENCE CHINA-LIFE SCIENCES
卷 57, 期 8, 页码 774-780出版社
SCIENCE PRESS
DOI: 10.1007/s11427-014-4716-0
关键词
Notch pathway; vascular morphogenesis; vascular homeostasis; endothelial cells; mural cells
类别
资金
- National Natural Science Foundation of China [91339115, 31370769, 30830067]
Notch signaling is an evolutionarily conserved intercellular signaling pathway that plays numerous crucial roles in vascular development and physiology. Compelling evidence indicates that Notch signaling is vital for vascular morphogenesis including arterial and venous differentiation and endothelial tip and stalk cell specification during sprouting angiogenesis and also vessel maturation featured by mural cell differentiation and recruitment. Notch signaling is also required for vascular homeostasis in adults by keeping quiescent phalanx cells from re-entering cell cycle and by modulating the behavior of endothelial progenitor cells. We will summarize recent advances of Notch pathway in vascular biology with special emphasis on the underlying molecular mechanisms.
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