期刊
SCIENCE CHINA-INFORMATION SCIENCES
卷 54, 期 4, 页码 898-908出版社
SCIENCE PRESS
DOI: 10.1007/s11432-010-4175-6
关键词
biomedical microelectronics; visual prosthesis; functional electrical stimulation; acute animal experiment; electrical evoked potential (EEP) test
资金
- National Natural Science Foundation of China [60776024, 60877035, 90820002]
- National High-Tech Research & Development Program of China [2007AA04Z329, 2007AA04Z254]
A prototype chip with 2x2 pixels for implanting in blind patients affected by outer retinal degeneration is presented in this paper. This visual prosthesis chip imitates the degenerated photoreceptor cells, senses the incident light and stimulates the remaining healthy layers of retina or optic nerve. Each pixel integrates photodiode and stimulus pulse generator, converting the illumination on the eyes into 3-bit resolution bi-phasic current pulses. On-chip charge cancellation modules are used to discharge each electrode site for tissue safety. The prototype chip is designed and fabricated in 0.18-mu m N-well CMOS (complementary metal oxide semiconductor) 1P6M Mix-signal process, with a +/- 2.5 V dual voltage supply. The functionality of the fabricated chip is demonstrated on anesthetized rabbits. Neural responses in visual cortex are successfully evoked by the neuro-stimulus chip through an on-board trigger interface and flexible electrode.
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