期刊
SCIENCE CHINA-CHEMISTRY
卷 57, 期 12, 页码 1605-1614出版社
SCIENCE PRESS
DOI: 10.1007/s11426-014-5235-3
关键词
DNA G-quadruplexes; oncogene promoters; human telomeres; G-quadruplex-targeted small molecules; anticancer drug target
资金
- NCI NIH HHS [R01 CA122952, R01 CA153821, R01 CA177585] Funding Source: Medline
- NIGMS NIH HHS [R01 GM083117] Funding Source: Medline
G-quadruplex secondary structures are four-stranded globular nucleic acid structures form in the specific DNA and RNA G-rich sequences with biological significance such as human telomeres, oncogene-promoter regions, replication initiation sites, and 5' and 3'-untranslated (UTR) regions. The non-canonical G-quadruplex secondary structures can readily form under physiologically relevant ionic conditions and are considered to be new molecular target for cancer therapeutics. This review discusses the essential progress in our lab related to the structures and functions of biologically relevant DNA G-quadruplexes in human gene promoters and telomeres, and the opportunities presented for the development of G-quadruplex-targeted small-molecule drugs.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据