期刊
SCIENCE CHINA-CHEMISTRY
卷 56, 期 9, 页码 1228-1233出版社
SCIENCE PRESS
DOI: 10.1007/s11426-013-4936-3
关键词
aggregation-induced emission; AIE dots; targeted imaging; fluorescence imaging
资金
- Agency for Science Technology and Research Joint Council and Institute of Materials Research and Engineering of Singapore [IMRE/13-8P1104]
- Singapore National Research Foundation [R-279-000-390-281]
- Research Grants Council of Hong Kong [603509, HKUST2/CRF/10, 604711, N_HKUST620/11]
- Guangdong Innovative Research Team Program [201101C0105067115]
Fluorescent probes play a key role in modern biomedical research. As compared to inorganic quantum dots (QDs) composed with heavy metal elements, organic dye-based fluorescent nanoparticles have higher biocompatibility and are richer in variety. However, traditional organic fluorophores tend to quench fluorescence upon aggregation, which is known as aggregation-caused quenching (ACQ) effect that hinders the fabrication of highly emissive fluorescent nanoparticles. In this work, we demonstrate the synthesis of organic fluorescent dots with aggregation-induced emission (AIE) in far-red/near-infrared (FA/NIR) region. A conventional ACQ-characteristic fluorescent dye, 3,4:9,10-tetracarboxylic perylene bisimide (PBI), is converted into an AIE fluorogen through attaching two tetraphenylethylene (TPE) moieties. The fluorescent dots with surface folic acid groups are fabricated from PBI derivative (DTPEPBI), showing specific targeting effect to folate receptor-overexpressed cancer cells. In vivo studies also suggest that the folic acid-functionalized AIE dots preferentially accumulate in the tumor site through enhanced permeability and retention (EPR) effect and folate receptor-mediated active targeting effect. The low cytotoxicity, good FR/NIR contrast and excellent targeting ability in in vitro/in vivo imaging indicate that the AIE dots have great potentials in advanced bioimaging applications.
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