Overcoming multidrug resistance (MDR) in cancer by nanotechnology

The emerging nanotechnology-based drug delivery holds tremendous potential to deliver chemotherapeutic drugs for treatment of multidrug resistance (MDR) cancer. This drug delivery system could improve the pharmacokinetic behavior of antitumor drugs, deliver chemotherapeutic drugs to target sites, control release of drugs, and reduce the systemic toxicity of drugs in MDR cancer. This review addresses the use of nanotechnology to overcome MDR classified on the bases of the fundamental mechanisms of MDR and various approaches to deliver drugs for treatment of MDR cancer.