4.8 Article

Shifting the limits in wheat research and breeding using a fully annotated reference genome

期刊

SCIENCE
卷 361, 期 6403, 页码 661-+

出版社

AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aar7191

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资金

  1. Agence Nationale pour la Recherche (ANR) [ANR-11-BSV5-0015-Ploid-Ploid, ANR-16-TERC-0026-01-3DWHEAT]
  2. Agriculture and Agri-Food Canada
  3. Alberta Wheat Development Commission through the Canadian Applied Tricticum Genomics (CTAG2)
  4. Australian Government, Department of Industry, Innovation, Climate Change, Science, Research, and Tertiary Education, Australia China Science and Research Fund Group Mission [ACSRF00542]
  5. Australian Research Council Centre of Excellence in Plant Energy Biology [CE140100008]
  6. Australian Research Council [FL140100179]
  7. Bayer CropScience
  8. Biotechnology and Biological Sciences Research Council (BBSRC) [BB/J00426X/1, BB/J004669/1, BB/P016855/1, BB/J003557/1, BB/M014045/1]
  9. Canada First Research Excellence Fund through the Designing Crops for Global Food Security initiative at the University of Saskatchewan
  10. Council for Agricultural Research and Economics, Italy, through CREA-Interomics
  11. Department of Biotechnology, Ministry of Science and Technology, Government of India [BT/IWGSC/03/TF/2008]
  12. DFG [SFB924]
  13. European Commission through the TriticeaeGenome [FP7-212019]
  14. France Genomique Genome Canada through the CTAG2 project [ANR-10-INBS-09]
  15. Genome Prairie through the CTAG2 project
  16. German Academic Exchange Service (DAAD) PPP Australien [1j16]
  17. German Federal Ministry of Food and Agriculture [2819103915 WHEATSEQ]
  18. German Ministry of Education and Research [031A536 de.NBI]
  19. Global Institute for Food Security Genomics and Bioinformatics fund
  20. Gordon and Betty Moore Foundation [GBMF4725]
  21. Grain Research Development Corporation (GRDC) Australia
  22. Graminor AS NFR project [199387]
  23. illumina
  24. INRA, French National Institute for Agricultural Research
  25. International Wheat Genome Sequencing Consortium
  26. Israel Science Foundation [999/12, 1137/17, 1824/12]
  27. Junta de Andalucia, Spain [P12-AGR-0482]
  28. MINECO (Spanish Ministry of Economy, Industry, and Competitiveness) [BIO2011-15237-E]
  29. Ministry of Agriculture, Forestry, and Fisheries of Japan through Genomics for Agricultural Innovation [KGS-1003]
  30. Ministry of Agriculture, Forestry, and Fisheries of Japan through Genomics-based Technology for Agricultural Improvement [NGB-1003]
  31. Ministry of Education and Science of Russian Federation [RFMEFI60414X0106, RFMEFI60414 X0107]
  32. Ministry of Education, Youth, and Sport of the Czech Republic [LO1204]
  33. Nisshin Flour Milling, Inc.
  34. National Research Council of Canada
  35. Norwegian University of Life Sciences (NMBU) NFR project [199387]
  36. National Science Foundation, United States [1339389, DBI-0701916, IIP-1338897]
  37. Russian Science Foundation [14-14-00161]
  38. Saskatchewan Ministry of Agriculture through the CTAG2 project
  39. Saskatchewan Wheat Development Commission through the CTAG2 project
  40. Czech Science Foundation [521/06/1723, 521-08-1629, P501/10/1740, P501/12/2554, P501/12/G090, 14-07164S, 13-08786S]
  41. Research Council of Norway [199387]
  42. U.S. Department of Agriculture NIFA [2008-35300-04588]
  43. University of Zurich
  44. Western Grains Research Foundation
  45. Western Grains Research Foundation National Wheat Improvement Program
  46. Winifred-Asbjornson Plant Science Endowment Fund
  47. French Government [ANR-10-BTBR-03]
  48. FranceAgriMer [2011-0971, 2013-0544]
  49. INRA
  50. NBI Computing infrastructure for Science (CiS) group through the HPC cluster
  51. NIFA [583116, 2008-35300-04588] Funding Source: Federal RePORTER
  52. BBSRC [BBS/E/J/000PR9795, BB/P010768/1, BBS/E/C/000I0250, BBS/E/C/00005203, BB/L009293/1, BB/J003743/1, BB/H019820/1, BBS/E/J/000PR9787, BBS/E/J/000C0628, BBS/E/J/000PR9789, BBS/E/J/000PR9780, BBS/E/T/000PR5885, BBS/E/J/000PR9779, BB/M014045/1, BBS/E/T/000PR9784, BBS/E/J/000PR9798, BB/P021646/1, BBS/E/T/000PR9819, BB/N020413/1] Funding Source: UKRI
  53. Russian Science Foundation [17-14-00021] Funding Source: Russian Science Foundation

向作者/读者索取更多资源

An annotated reference sequence representing the hexaploid bread wheat genome in 21 pseudomolecules has been analyzed to identify the distribution and genomic context of coding and noncoding elements across the A, B, and D subgenomes. With an estimated coverage of 94% of the genome and containing 107,891 high-confidence gene models, this assembly enabled the discovery of tissue-and developmental stage-related coexpression networks by providing a transcriptome atlas representing major stages of wheat development. Dynamics of complex gene families involved in environmental adaptation and end-use quality were revealed at subgenome resolution and contextualized to known agronomic single-gene or quantitative trait loci. This community resource establishes the foundation for accelerating wheat research and application through improved understanding of wheat biology and genomics-assisted breeding.

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