期刊
SCIENCE
卷 361, 期 6401, 页码 469-474出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat1168
关键词
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资金
- Research Corporation, for Science Advancement
- Gordon and Betty Moore Foundation
- Boston University by the Research Corporation
- Simons Foundation.
- uman Frontier Science Program [RGY0077/2016]
- NIH NIGMS grant [1R35GM119461]
- Simons Investigator as in the Mathematical Modeling of Living Systems (MMLS)
- Defense Advanced Research Projects Agency [HR0011515303, HR0011-15-0-0091]
- NIH [T32GM100842, 5R01DE024468, R01GM121950, ub_P30DK036836]
- National Science Foundation [1457695]
- Human Frontier Science Program [RGP0020/2016]
- Boston University Interdisciplinary Biomedical Research Office
A major unresolved question in microbiome research is whether the complex taxonomic architectures observed in surveys of natural communities can be explained and predicted by fundamental, quantitative principles. Bridging theory and experiment is hampered by the multiplicity of ecological processes that simultaneously affect community assembly in natural ecosystems. We addressed this challenge by monitoring the assembly of hundreds of soil- and plant-derived microbiomes in well-controlled minimal synthetic media. Both the community-level function and the coarse-grained taxonomy of the resulting communities are highly predictable and governed by nutrient availability, despite substantial species variability. By generalizing classical ecological models to include widespread nonspecific cross-feeding, we show that these features are all emergent properties of the assembly of large microbial communities, explaining their ubiquity in natural microbiomes.
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