期刊
SCIENCE
卷 361, 期 6402, 页码 594-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat1699
关键词
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资金
- St. Baldrick's Foundation (Robert J. Arceci International Award)
- Wellcome
- Cambridge Biomedical Research Campus (biobanking infrastructure)
- CRUK Cambridge Centre (biobanking infrastructure)
- NIHR Blood and Transplant Research Unit
- MRC
- Arthritis Research UK
- Lister Institute for Preventative Medicine
- NIHR and Newcastle Biomedical Research Centre
- ISAC SRL-EL program
- joint Wellcome Trust-MRC funding
- Kidney Cancer UK
- Facing up 2 Kidney Cancer
- EMBO
- Human Frontier Science Program
- Children with Cancer UK
- MRC [MR/N024907/1, MR/M008975/1, G0700089, MR/K023934/1] Funding Source: UKRI
Messenger RNA encodes cellular function and phenotype. In the context of human cancer, it defines the identities of malignant cells and the diversity of tumor tissue. We studied 72,501 single-cell transcriptomes of human renal tumors and normal tissue from fetal, pediatric, and adult kidneys. We matched childhood Wilms tumor with specific fetal cell types. thus providing evidence for the hypothesis that Wilms tumor cells are aberrant fetal cells. In adult renal cell carcinoma, we identified a canonical cancer transcriptome that matched a little-known subtype of proximal convoluted tubular cell. Analyses of the tumor composition defined cancer-associated normal cells and delineated a complex vascular endothelial growth factor (VEGF) signaling circuit. Our findings reveal the precise cellular identities and compositions of human kidney tumors.
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