期刊
SCIENCE
卷 362, 期 6415, 页码 670-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.aat2299
关键词
-
资金
- National Institutes of Health [SC1GM110010]
- National Science Foundation [CHE-1665189, CHE-1361296, CHE-1763436]
- Leopoldina Fellowship Programme of the German National Academy of Sciences Leopoldina [LPDS 2017-18]
- Center for High Performance Computing (CHPC) at the University of Utah
- NSF [ACI-1548562]
- [TG-CHE180003]
Despite the enormous potential for the use of stereospecific cross-coupling reactions to rationally manipulate the three-dimensional structure of organic molecules, the factors that control the transfer of stereochemistry in these reactions remain poorly understood. Here we report a mechanistic and synthetic investigation into the use of enantioenriched alkylboron nucleophiles in stereospecific Pd-catalyzed Suzuki cross-coupling reactions. By developing a suite of molecular descriptors of phosphine ligands, we could apply predictive statistical models to select or design distinct ligands that respectively promoted stereoinvertive and stereoretentive cross-coupling reactions. Stereodefined branched structures were thereby accessed through the predictable manipulation of absolute stereochemistry, and a general model for the mechanism of alkylboron transmetallation was proposed.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据