期刊
SCIENCE
卷 345, 期 6195, 页码 437-440出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1255525
关键词
-
资金
- NIH [NIHGMS R01 GM103558-01, R01 GM100985-01]
- Shanghai Institute of Organic Chemistry
Over the past 40 years, transition metal catalysis has enabled bond formation between aryl and olefinic (sp(2)) carbons in a selective and predictable manner with high functional group tolerance. Couplings involving alkyl (sp(3)) carbons have proven more challenging. Here, we demonstrate that the synergistic combination of photoredox catalysis and nickel catalysis provides an alternative cross-coupling paradigm, in which simple and readily available organic molecules can be systematically used as coupling partners. By using this photoredox-metal catalysis approach, we have achieved a direct decarboxylative sp(3)-sp(2) cross-coupling of amino acids, as well as alpha-O- or phenyl-substituted carboxylic acids, with aryl halides. Moreover, this mode of catalysis can be applied to direct cross-coupling of C-sp3-H in dimethylaniline with aryl halides via C-H functionalization.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据