期刊
SCIENCE
卷 345, 期 6200, 页码 1074-1079出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1253714
关键词
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资金
- National Human Genome Research Institute [U54 HG003067]
- European Research Council
- Wellcome Trust [WT095908, WT098051]
- NIH, NIAID
- European Molecular Biology Laboratory
- European Social Fund
- Portuguese Ministerio da Ciencia, Tecnologia e Ensino Superior [SFRH/BPD/72343/2010, SFRH/BPD/64365/2009, SFRH/BD/72381/2010]
- NSF [OISE-0754461]
- FEDER through COMPETE program
- Fundacao para a Ciencia e a Tecnologia [PTDC/CVT/122943/2010, PTDC/BIA-EVF/115069/2009, PTDC/BIA-BDE/72304/2006, PTDC/BIA-BDE/72277/2006]
- project Genomics and Evolutionary Biology - North Portugal Regional Operational Programme (ON.2 - O Novo Norte) under National Strategic Reference Framework
- project Genomics Applied to Genetic Resources - North Portugal Regional Operational Programme (ON.2 - O Novo Norte) under National Strategic Reference Framework
- European Regional Development Fund (COST Action) [TD1101]
- Higher Education Commission in Pakistan
- Biotechnology and Biological Sciences Research Council [BBS/E/T/000PR5885, BBS/E/T/000PR6193] Funding Source: researchfish
- Fundação para a Ciência e a Tecnologia [PTDC/CVT/122943/2010, SFRH/BD/72381/2010, SFRH/BPD/64365/2009, PTDC/BIA-EVF/115069/2009, PTDC/BIA-BDE/72304/2006, PTDC/BIA-BDE/72277/2006] Funding Source: FCT
- BBSRC [BBS/E/T/000PR5885, BBS/E/T/000PR6193] Funding Source: UKRI
The genetic changes underlying the initial steps of animal domestication are still poorly understood. We generated a high-quality reference genome for the rabbit and compared it to resequencing data from populations of wild and domestic rabbits. We identified more than 100 selective sweeps specific to domestic rabbits but only a relatively small number of fixed (or nearly fixed) single-nucleotide polymorphisms (SNPs) for derived alleles. SNPs with marked allele frequency differences between wild and domestic rabbits were enriched for conserved noncoding sites. Enrichment analyses suggest that genes affecting brain and neuronal development have often been targeted during domestication. We propose that because of a truly complex genetic background, tame behavior in rabbits and other domestic animals evolved by shifts in allele frequencies at many loci, rather than by critical changes at only a few domestication loci.
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