期刊
SCIENCE
卷 346, 期 6210, 页码 755-759出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1257147
关键词
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资金
- NIH [R01 AI080611, R21 AI103961]
- National Institute of Food and Agriculture [2011-68003-30395]
- NIH/National Institute of Dental and Craniofacial Research [T90 DE021990-02]
The cell tropism of human noroviruses and the development of an in vitro infection model remain elusive. Although susceptibility to individual human norovirus strains correlates with an individual's histo-blood group antigen (HBGA) profile, the biological basis of this restriction is unknown. We demonstrate that human and mouse noroviruses infected B cells in vitro and likely in vivo. Human norovirus infection of B cells required the presence of HBGA-expressing enteric bacteria. Furthermore, mouse norovirus replication was reduced in vivo when the intestinal microbiota was depleted by means of oral antibiotic administration. Thus, we have identified B cells as a cellular target of noroviruses and enteric bacteria as a stimulatory factor for norovirus infection, leading to the development of an in vitro infection model for human noroviruses.
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