期刊
SCIENCE
卷 345, 期 6196, 页码 566-570出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1252960
关键词
-
资金
- CRG
- ICREA
- Fundacao para a Ciencia e Tecnologia
- Ministerio de Economia y Competitividad (MINECO) [BFU2010-16428]
- Centro de Excelencia Severo Ochoa [SEV-2012-0208]
- ICREA Funding Source: Custom
During limb development, digits emerge from the undifferentiated mesenchymal tissue that constitutes the limb bud. It has been proposed that this process is controlled by a self-organizing Turing mechanism, whereby diffusible molecules interact to produce a periodic pattern of digital and interdigital fates. However, the identities of the molecules remain unknown. By combining experiments and modeling, we reveal evidence that a Turing network implemented by Bmp, Sox9, and Wnt drives digit specification. We develop a realistic two-dimensional simulation of digit patterning and show that this network, when modulated by morphogen gradients, recapitulates the expression patterns of Sox9 in the wild type and in perturbation experiments. Our systems biology approach reveals how a combination of growth, morphogen gradients, and a self-organizing Turing network can achieve robust and reproducible pattern formation.
作者
我是这篇论文的作者
点击您的名字以认领此论文并将其添加到您的个人资料中。
推荐
暂无数据