期刊
SCIENCE
卷 345, 期 6200, 页码 1048-1052出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1254529
关键词
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资金
- Alfred P. Sloan Foundation's Microbiology of the Built Environment Program
- NIH Director's New Innovator Award [DP2-DK-098089]
- U.S. Environmental Protection Agency STAR Fellowship
- NSF [DGE-11143954]
- U.S. Department of Energy [DE-AC02-06CH11357]
- University of Chicago Research Computing Center
The bacteria that colonize humans and our built environments have the potential to influence our health. Microbial communities associated with seven families and their homes over 6 weeks were assessed, including three families that moved their home. Microbial communities differed substantially among homes, and the home microbiome was largely sourced from humans. The microbiota in each home were identifiable by family. Network analysis identified humans as the primary bacterial vector, and a Bayesian method significantly matched individuals to their dwellings. Draft genomes of potential human pathogens observed on a kitchen counter could be matched to the hands of occupants. After a house move, the microbial community in the new house rapidly converged on the microbial community of the occupants' former house, suggesting rapid colonization by the family's microbiota.
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