期刊
SCIENCE
卷 344, 期 6184, 页码 598-602出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1248903
关键词
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资金
- Brain Canada
- Canadian Institutes of Health Research (CIHR) [MOP86762, MOP74650]
- Centre for Brain and Behavior at the Hospital for Sick Children
- Core Research for Evolutional Science and Technology of Japan Science and Technology Agency (JST-CREST)
- Ministry of Education, Culture, Sports, Science and Technology Grants-in-Aid for Scientific Research (KAKENHI)
- CIHR
- El Consejo Nacional de Ciencia y Tecnologia
- Donald and Doris Milne Alzheimer's Disease Fellowship
- Ontario Mental Health Foundation
- Natural Sciences and Engineering Research Council of Canada
- Grants-in-Aid for Scientific Research [25116526, 25242078] Funding Source: KAKEN
Throughout life, new neurons are continuously added to the dentate gyrus. As this continuous addition remodels hippocampal circuits, computational models predict that neurogenesis leads to degradation or forgetting of established memories. Consistent with this, increasing neurogenesis after the formation of a memory was sufficient to induce forgetting in adult mice. By contrast, during infancy, when hippocampal neurogenesis levels are high and freshly generated memories tend to be rapidly forgotten (infantile amnesia), decreasing neurogenesis after memory formation mitigated forgetting. In precocial species, including guinea pigs and degus, most granule cells are generated prenatally. Consistent with reduced levels of postnatal hippocampal neurogenesis, infant guinea pigs and degus did not exhibit forgetting. However, increasing neurogenesis after memory formation induced infantile amnesia in these species.
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