期刊
SCIENCE
卷 345, 期 6202, 页码 1369-1372出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1259657
关键词
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资金
- NSF Graduate Research Fellowship Program
- NIH grant [GM080177, 1DP2OD006514-01]
- NIH [1U01HG007480-01]
- World Bank
- European Union [FP7/2007-2013 278433-PREDEMICS]
- European Research Council [260864]
- Natural Environment Research Council grant [D76739X]
- National Institute of Allergy and Infectious Diseases grant [HHSN272200900049C]
- Natural Environment Research Council [1086074] Funding Source: researchfish
In its largest outbreak, Ebola virus disease is spreading through Guinea, Liberia, Sierra Leone, and Nigeria. We sequenced 99 Ebola virus genomes from 78 patients in Sierra Leone to similar to 2000x coverage. We observed a rapid accumulation of interhost and intrahost genetic variation, allowing us to characterize patterns of viral transmission over the initial weeks of the epidemic. This West African variant likely diverged from central African lineages around 2004, crossed from Guinea to Sierra Leone in May 2014, and has exhibited sustained human-to-human transmission subsequently, with no evidence of additional zoonotic sources. Because many of the mutations alter protein sequences and other biologically meaningful targets, they should be monitored for impact on diagnostics, vaccines, and therapies critical to outbreak response.
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