期刊
SCIENCE
卷 345, 期 6193, 页码 179-183出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1254194
关键词
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资金
- Federal funds from the National Cancer Institute, an NIH
- National Cancer Institute [HSSN261200800001E, 25XS119]
- American Cancer Society
- F. M. Kirby Foundation
The persistence of HIV-infected cells in individuals on suppressive combination antiretroviral therapy (cART) presents a major barrier for curing HIV infections. HIV integrates its DNA into many sites in the host genome; we identified 2410 integration sites in peripheral blood lymphocytes of five infected individuals on cART. About 40% of the integrations were in clonally expanded cells. Approximately 50% of the infected cells in one patient were from a single clone, and some clones persisted for many years. There were multiple independent integrations in several genes, including MKL2 and BACH2; many of these integrations were in clonally expanded cells. Our findings show that HIV integration sites can play a critical role in expansion and persistence of HIV-infected cells.
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