期刊
SCIENCE
卷 344, 期 6181, 页码 304-307出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1248571
关键词
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资金
- Ministry of Education, Culture, Sports, Science and Technology of Japan [22227004, 24227004]
- Japan New Energy and Industrial Technology Development Organization (NEDO)
- National Institute of Biomedical Innovation
- Grants-in-Aid for Scientific Research [22227004, 22770147, 25650019, 22117007, 26440024] Funding Source: KAKEN
Tight junctions are cell-cell adhesion structures in epithelial cell sheets that surround organ compartments in multicellular organisms and regulate the permeation of ions through the intercellular space. Claudins are the major constituents of tight junctions and form strands that mediate cell adhesion and function as paracellular barriers. We report the structure of mammalian claudin-15 at a resolution of 2.4 angstroms. The structure reveals a characteristic beta-sheet fold comprising two extracellular segments, which is anchored to a transmembrane four-helix bundle by a consensus motif. Our analyses suggest potential paracellular pathways with distinctive charges on the extracellular surface, providing insight into the molecular basis of ion homeostasis across tight junctions.
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