期刊
SCIENCE
卷 344, 期 6182, 页码 380-386出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1249656
关键词
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资金
- Wellcome Trust [085775/Z/08/Z, 098051]
- World Health Organization (WHO) Special Programme for Research and Training in Tropical Diseases (TDR) [A90088]
- Ambrose Monell Foundation
- Food and Agriculture Organization/International Atomic Energy Agency Coordinated Research Program Improving SIT for Tsetse Flies through Research on their Symbionts
- European Union Cooperation in Science and Technology (COST) Action [FA0701]
- Ministry of Education, Culture, Sports, Science, and Technology of Japan
- BBSRC [BB/J017698/1, BBS/E/C/00005194, BBS/E/C/00005193] Funding Source: UKRI
- MRC [MR/K002279/1] Funding Source: UKRI
- Division Of Integrative Organismal Systems
- Direct For Biological Sciences [0951886] Funding Source: National Science Foundation
- Biotechnology and Biological Sciences Research Council [BBS/E/C/00005193, BB/J017698/1, BBS/E/C/00005194] Funding Source: researchfish
- Medical Research Council [MR/K002279/1] Funding Source: researchfish
Tsetse flies are the sole vectors of human African trypanosomiasis throughout sub-Saharan Africa. Both sexes of adult tsetse feed exclusively on blood and contribute to disease transmission. Notable differences between tsetse and other disease vectors include obligate microbial symbioses, viviparous reproduction, and lactation. Here, we describe the sequence and annotation of the 366-megabase Glossina morsitans morsitans genome. Analysis of the genome and the 12,308 predicted protein-encoding genes led to multiple discoveries, including chromosomal integrations of bacterial (Wolbachia) genome sequences, a family of lactation-specific proteins, reduced complement of host pathogen recognition proteins, and reduced olfaction/ chemosensory associated genes. These genome data provide a foundation for research into trypanosomiasis prevention and yield important insights with broad implications for multiple aspects of tsetse biology.
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