期刊
SCIENCE
卷 345, 期 6194, 页码 -出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1247125
关键词
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资金
- European Molecular Biology Organization (EMBO)
- Helen Hay Whitney Foundation
- Marie Curie post-doctoral fellowship
- Austrian Academy of Sciences
- Austrian Science Fund (FWF) [Z153-B09, I552-B19]
- European Research Council
- Austrian Science Fund (FWF) [Z 153] Funding Source: researchfish
- Austrian Science Fund (FWF) [Z153] Funding Source: Austrian Science Fund (FWF)
Classical experiments performed half a century ago demonstrated the immense self-organizing capacity of vertebrate cells. Even after complete dissociation, cells can reaggregate and reconstruct the original architecture of an organ. More recently, this outstanding feature was used to rebuild organ parts or even complete organs from tissue or embryonic stem cells. Such stem cell-derived three-dimensional cultures are called organoids. Because organoids can be grown from human stem cells and from patient-derived induced pluripotent stem cells, they have the potential to model human development and disease. Furthermore, they have potential for drug testing and even future organ replacement strategies. Here, we summarize this rapidly evolving field and outline the potential of organoid technology for future biomedical research.
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