期刊
SCIENCE
卷 344, 期 6179, 页码 65-69出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1250944
关键词
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资金
- Office of Naval Research (ONR) [N000141110914]
- ONR [N000141010827, N000141310593]
- Army Research Office [W911NF1210238]
- National Institutes of Health (NIH) [1DP2OD007292, 1R01EB018659, 5R21HD072481]
- National Science Foundation (NSF) [CCF1054898, CCF1317291, CCF1162459, CMMI1333215]
- JSR corporation
- Wyss Institute for Biologically Inspired Engineering Faculty Startup Fund
- Alexander von Humboldt Foundation
- U.S. Department of Defense (DOD) [W911NF1210238] Funding Source: U.S. Department of Defense (DOD)
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1054898] Funding Source: National Science Foundation
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [1317694] Funding Source: National Science Foundation
DNA self-assembly has produced diverse synthetic three-dimensional polyhedra. These structures typically have a molecular weight no greater than 5 megadaltons. We report a simple, general strategy for one-step self-assembly of wireframe DNA polyhedra that are more massive than most previous structures. A stiff three-arm-junction DNA origami tile motif with precisely controlled angles and arm lengths was used for hierarchical assembly of polyhedra. We experimentally constructed a tetrahedron (20 megadaltons), a triangular prism (30 megadaltons), a cube (40 megadaltons), a pentagonal prism (50 megadaltons), and a hexagonal prism (60 megadaltons) with edge widths of 100 nanometers. The structures were visualized by means of transmission electron microscopy and three-dimensional DNA-PAINT super-resolution fluorescent microscopy of single molecules in solution.
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