期刊
SCIENCE
卷 346, 期 6215, 页码 1334-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1256780
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资金
- American Psychological Association - National Institute of Mental Health [5T32MH018882-18]
- National Science Foundation [0610337]
- National Institute on Deafness and Other Communication Disorders [R01DC007218]
- Howard Hughes Medical Institute
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0644282] Funding Source: National Science Foundation
- Direct For Biological Sciences
- Div Of Biological Infrastructure [0610337] Funding Source: National Science Foundation
- Direct For Mathematical & Physical Scien
- Division Of Mathematical Sciences [1209155] Funding Source: National Science Foundation
Songbirds represent an important model organism for elucidating molecular mechanisms that link genes with complex behaviors, in part because they have discrete vocal learning circuits that have parallels with those that mediate human speech. We found that similar to 10% of the genes in the avian genome were regulated by singing, and we found a striking regional diversity of both basal and singing-induced programs in the four key song nuclei of the zebra finch, a vocal learning songbird. The region-enriched patterns were a result of distinct combinations of region-enriched transcription factors (TFs), their binding motifs, and presinging acetylation of histone 3 at lysine 27 (H3K27ac) enhancer activity in the regulatory regions of the associated genes. RNA interference manipulations validated the role of the calcium-response transcription factor (CaRF) in regulating genes preferentially expressed in specific song nuclei in response to singing. Thus, differential combinatorial binding of a small group of activity-regulated TFs and predefined epigenetic enhancer activity influences the anatomical diversity of behaviorally regulated gene networks.
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