期刊
SCIENCE
卷 344, 期 6186, 页码 901-904出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1252114
关键词
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资金
- Wellcome Trust
- Gatsby Charitable Foundation
- NIH
- Oxford Martin School
- Human Frontier Science Program
- Fundacao Champalimaud
- Fundacao para a Ciencia e Tecnologia
- Marie Curie Actions Fellowships
- Wellcome Trust [090309/Z/09/Z] Funding Source: Wellcome Trust
- MRC [G0700888, G0701225] Funding Source: UKRI
- Medical Research Council [G0700888, G0701225] Funding Source: researchfish
- Wellcome Trust [090309/Z/09/Z] Funding Source: researchfish
Decisions take time if information gradually accumulates to a response threshold, but the neural mechanisms of integration and thresholding are unknown. We characterized a decision process in Drosophila that bears the behavioral signature of evidence accumulation. As stimulus contrast in trained odor discriminations decreased, reaction times increased and perceptual accuracy declined, in quantitative agreement with a drift-diffusion model. FoxP mutants took longer than wild-type flies to form decisions of similar or reduced accuracy, especially in difficult, low-contrast tasks. RNA interference with FoxP expression in ab core Kenyon cells, or the overexpression of a potassium conductance in these neurons, recapitulated the FoxP mutant phenotype. A mushroom body subdomain whose development or function require the transcription factor FoxP thus supports the progression of a decision toward commitment.
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