期刊
SCIENCE
卷 345, 期 6195, 页码 455-459出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1249749
关键词
-
资金
- CORE grant [CA34196]
- National Science Foundation [0850155]
In higher eukaryotes, transfer RNAs (tRNAs) with the same anticodon are encoded by multiple nuclear genes, and little is known about how mutations in these genes affect translation and cellular homeostasis. Similarly, the surveillance systems that respond to such defects in higher eukaryotes are not clear. Here, we discover that loss of GTPBP2, a novel binding partner of the ribosome recycling protein Pelota, in mice with a mutation in a tRNA gene that is specifically expressed in the central nervous system causes ribosome stalling and widespread neurodegeneration. Our results not only define GTPBP2 as a ribosome rescue factor but also unmask the disease potential of mutations in nuclear-encoded tRNA genes.
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