期刊
SCIENCE
卷 343, 期 6166, 页码 37-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1235681
关键词
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资金
- International AIDS Initiative (IAVI)
- Scripps Center for HIV/AIDS Vaccine Immunology and Discovery (CHAVI-ID)
- Medical Research Council
- United Therapeutics Corporation, USA
- Oxford Glycobiology Institute
- MRC [MC_PC_12020] Funding Source: UKRI
- Medical Research Council [MC_PC_12020] Funding Source: researchfish
Glycosylation plays a key role in a wide range of biological processes. Specific modification to a glycan's structure can directly modulate its biological function. Glycans are not only essential to glycoprotein folding, cellular homeostasis, and immune regulation but are involved in multiple disease conditions. An increased molecular and structural understanding of the mechanistic role that glycans play in these pathological processes has driven the development of therapeutics and illuminated novel targets for drug design. This knowledge has enabled the treatment of metabolic disorders and the development of antivirals and shaped cancer and viral vaccine strategies. Furthermore, an understanding of glycosylation has led to the development of specific drug glycoforms, for example, monoclonal antibodies, with enhanced potency.
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