期刊
SCIENCE
卷 343, 期 6171, 页码 645-648出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1248229
关键词
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资金
- Max Planck Society
- Agence Nationale de la Recherche [Charmful SVSE2-2011]
- Cooperations et Mobilites Internationales Rhone-Alpes
- FP7 P-CUBE [227764]
- Alberta Ministry of Enterprise and Advanced Education
- Alberta Innovates Technology Futures
- Innovates Centre of Research Excellence
- Musea Ventures
- BGI-Shenzhen
- Natural Environment Research Council [NE/K009303/1] Funding Source: researchfish
- NERC [NE/K009303/1] Funding Source: UKRI
Transcription factors (TFs) are key players in evolution. Changes affecting their function can yield novel life forms but may also have deleterious effects. Consequently, gene duplication events that release one gene copy from selective pressure are thought to be the common mechanism by which TFs acquire new activities. Here, we show that LEAFY, a major regulator of flower development and cell division in land plants, underwent changes to its DNA binding specificity, even though plant genomes generally contain a single copy of the LEAFY gene. We examined how these changes occurred at the structural level and identify an intermediate LEAFY form in hornworts that appears to adopt all different specificities. This promiscuous intermediate could have smoothed the evolutionary transitions, thereby allowing LEAFY to evolve new binding specificities while remaining a single-copy gene.
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