期刊
SCIENCE
卷 343, 期 6172, 页码 769-772出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1248286
关键词
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资金
- NIH [GM084056]
- NSF [0920090]
- Direct For Biological Sciences [0920090] Funding Source: National Science Foundation
- Div Of Molecular and Cellular Bioscience [0920090] Funding Source: National Science Foundation
Comparative genomic analyses have revealed that genes may arise from ancestrally nongenic sequence. However, the origin and spread of these de novo genes within populations remain obscure. We identified 142 segregating and 106 fixed testis-expressed de novo genes in a population sample of Drosophila melanogaster. These genes appear to derive primarily from ancestral intergenic, unexpressed open reading frames, with natural selection playing a significant role in their spread. These results reveal a heretofore unappreciated dynamism of gene content.
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