期刊
SCIENCE
卷 345, 期 6198, 页码 799-804出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1253920
关键词
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资金
- Danish Council for Independent Research (Sapere Aude Starting Grant) [DFF-0602-01772]
- Danish National Research Foundation funding Centre for DNA Nanotechnology [DNRF81]
- U.S. National Science Foundation for Expeditions in Computing [0832824]
- Army Research Office [W911NF-11-1-0117]
- Direct For Computer & Info Scie & Enginr
- Division of Computing and Communication Foundations [0832824] Funding Source: National Science Foundation
- Division of Computing and Communication Foundations
- Direct For Computer & Info Scie & Enginr [1317694] Funding Source: National Science Foundation
Artificial DNA and RNA structures have been used as scaffolds for a variety of nanoscale devices. In comparison to DNA structures, RNA structures have been limited in size, but they also have advantages: RNA can fold during transcription and thus can be genetically encoded and expressed in cells. We introduce an architecture for designing artificial RNA structures that fold from a single strand, in which arrays of antiparallel RNA helices are precisely organized by RNA tertiary motifs and a new type of crossover pattern. We constructed RNA tiles that assemble into hexagonal lattices and demonstrated that lattices can be made by annealing and/or cotranscriptional folding. Tiles can be scaled up to 660 nucleotides in length, reaching a size comparable to that of large natural ribozymes.
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