期刊
SCIENCE
卷 345, 期 6198, 页码 829-832出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1255550
关键词
-
资金
- Israel Science Foundation
- Minerva Foundation
- U.S.-Israel Binational Science Foundation
- NSF [PHY-0750133]
- Azrieli Foundation
The assembly of artificial cells capable of executing synthetic DNA programs has been an important goal for basic research and biotechnology. We assembled two-dimensional DNA compartments fabricated in silicon as artificial cells capable of metabolism, programmable protein synthesis, and communication. Metabolism is maintained by continuous diffusion of nutrients and products through a thin capillary, connecting protein synthesis in the DNA compartment with the environment. We programmed protein expression cycles, autoregulated protein levels, and a signaling expression gradient, equivalent to a morphogen, in an array of interconnected compartments at the scale of an embryo. Gene expression in the DNA compartment reveals a rich, dynamic system that is controlled by geometry, offering a means for studying biological networks outside a living cell.
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