期刊
SCIENCE
卷 346, 期 6205, 页码 53-+出版社
AMER ASSOC ADVANCEMENT SCIENCE
DOI: 10.1126/science.1247390
关键词
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资金
- Medical Research Council (MRC)
- Engineering and Physical Sciences Research Council (EPSRC)
- Marie Curie International Incoming Fellowship within 7th European Community Framework Programme [PIIF-GA-2011-299936]
- EPSRC through Interdisciplinary Research Centre (IRC) [EP/K031953/1, EP/K020641/1]
- Engineering and Physical Sciences Research Council [EP/K031953/1, EP/K020641/1] Funding Source: researchfish
- Medical Research Council [MC_PC_13064, MC_PC_12015] Funding Source: researchfish
- EPSRC [EP/K020641/1, EP/K031953/1] Funding Source: UKRI
- MRC [MC_PC_13064, MC_PC_12015] Funding Source: UKRI
Colloidal nanoparticle biosensors have received intense scientific attention and offer promising applications in both research and medicine. We review the state of the art in nanoparticle development, surface chemistry, and biosensing mechanisms, discussing how a range of technologies are contributing toward commercial and clinical translation. Recent examples of success include the ultrasensitive detection of cancer biomarkers in human serum and in vivo sensing of methyl mercury. We identify five key materials challenges, including the development of robust mass-scale nanoparticle synthesis methods, and five broader challenges, including the use of simulations and bioinformatics-driven experimental approaches for predictive modeling of biosensor performance. The resultant generation of nanoparticle biosensors will form the basis of high-performance analytical assays, effective multiplexed intracellular sensors, and sophisticated in vivo probes.
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